All functions

anno

Example annotation file for three pathways.

calc_kernel(<GWASdata>) lin_kernel(<GWASdata>) sia_kernel(<GWASdata>) net_kernel(<GWASdata>)

Calculate the kernel-matrix for a pathway

geno

Example genotypes for 50 individuals.

get_anno(<snp_info>,<pathway_info>)

Annotates SNPs via genes to pathways

get_network_matrix(<pathway>)

Function to calculate the network matrix for a pathway object

gwas

Example GWASdata object.

GWASdata() show(<GWASdata>) summary(<GWASdata>) GeneSNPsize(<GWASdata>)

S4 class for an object representing a Genome-wide Assocaition Study.

hsa04020

Example pathway object for pathway hsa04020.

hsa04022_info

Example pathway_info object for pathway hsa04022.

kangar00-package kangar00

kangar00 package

show(<kernel>) summary(<kernel>) plot(<kernel>,<missing>)

An S4 class representing a kernel matrix calculated for a pathway

show(<lkmt>) summary(<lkmt>)

An S4 class to represent the variance component test.

lkmt.net.kernel.hsa04020

Example test result for the network-based kernel for pathway hsa04020.

lkmt_test() score_test(<matrix>) davies_test(<matrix>)

A function to calculate the p-values for kernel matrices.

lowrank_kernel-class lowrank_kernel

An S4 class to represent a low-rank kernel for a SNPset at specified knots

make_psd(<matrix>)

Adjust network matrix to be positive semi-definite

net.kernel.hsa04020

Example network-based kernel matrix for pathway hsa04020.

pathway() show(<pathway>) summary(<pathway>) pathway2igraph(<pathway>) analyze(<pathway>) get_genes(<pathway>) plot(<pathway>,<missing>) sample_genes(<pathway>)

An S4 class to represent a gene-gene interaction network

pathway_info() show(<pathway_info>) summary(<pathway_info>)

An S4 class for an object assigning genes to pathways

pheno

Example phenotype file for 50 individuals.

read_geno(<character>)

read genotype data from file to one of several available objects, which can be passed to a GWASdata object GWASdata.

rewire_network(<pathway>)

Rewires interactions in a pathway, which go through a gene not represented by any SNPs in the considered GWASdata dataset.

rs10243170_info

Example snp_info object for SNP rs10243170.

snp_info() show(<snp_info>) summary(<snp_info>)

An S4 class for an object assigning SNP positions to rs-numbers (for internal use)